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HRT History

On this page I’m tracking my HRT doses and blood tests. All of this is provided “as is”, with no implication that someone else should or should not do things the same way. (Except that I explicitly recommend to go for some form of DIY-HRT if you cannot get access to acceptable official HRT.)

Doses

My current medication consists of:

Substance Route Form Amount Location Dose Interval Product
Estradiol transdermal gel 4 pumps arm 3 mg 1∕day Oestrogel
Triptorelin intramuscular injection 1 buttock 11.25 mg 1∕12 weeks Pamorelin
Progesteron oral capsule 2 - 200 mg 1∕day Utrogestan
Minoxidil topical spray 2 sprays temples 6.67 mg 2∕day Minoxidil Teva 20 mg∕ml
Vitamin D oral capsule 1 - 75 μg 1∕day Vitamine D3 Forte

I am at this time happy with that protocol; two blood tests (that predate the daily progesterone and vitamin D) have confirmed at least the amount of estrogen to be reasonable. Minoxidil and Vitamin D are technically not part of my HRT regimen, but I include them here for completeness.

My full HRT treatment history.
Date Substance Route Form Location Dose Interval Product Reason
2024-02-04 Estradiol sublingual 💊 pill  1 mg 3∕day Estrofem Initial start with pills of a friend.
2024-02-14 Estradiol transdermal 🧴 gel arm 2.25 mg 1∕day Oestrogel Order of transdermal Estradiol and Finasteride arrives, starting with GenderGP recommendation
Finasteride oral 💊 pill 5 mg 1∕day
2024-02-29 Estradiol transdermal 🧴 gel arm  3 mg 1∕day Oestrogel Switch to DIY following bad experiences with GenderGP, using a dose based on community recommendations.
Cyproterone Acetate oral 💊 pill 12.5 mg 1∕day Androcur
2024-04-24 Estradiol transdermal 🧴 gel arm 4.5 mg 1∕day Oestrogel Increasing dose after being denied blood test to ensure sufficient Estradiol in any case.
Cyproterone Acetate oral 💊 pill 12.5 mg 1∕day Androcur
2024-07-09 Estradiol transdermal 🧴 gel arm ≈ 4 mg 1∕day Felicitas Switch to Homebrew-Estrogen due to price; Following recommended 2 pump dose.
Cyproterone Acetate oral 💊 pill 12.5 mg 1∕day Androcur
2024-08-19 Estradiol transdermal 🧴 gel arm ≈ 12 mg 1∕day Felicitas Dose increase after low E2 values in self-payed blood test (E2 cheaper than further tests).
Cyproterone Acetate oral 💊 pill 12.5 mg 1∕day Androcur
2024-10-11 Estradiol transdermal 🧴 gel arm ≈ 6 mg 1∕day Felicitas Dose decrease towards official starting dose (still higher to make drop less sudden).
Cyproterone Acetate oral 💊 pill 12.5 mg 1∕day Androcur
2024-10-14 Estradiol transdermal 🧴 gel arm 2.25 mg 2∕day Oestrogel Start with official HRT after receiving gel.
Cyproterone Acetate oral 💊 pill 12.5 mg 1∕day Androcur
2024-10-17 Estradiol transdermal 🧴 gel arm 2.25 mg 2∕day Oestrogel First Triptorelin injection. Initially keeping CPA to prevent the Testosterone flare.
Cyproterone Acetate oral 💊 pill 12.5 mg 1∕day Androcur
Triptorelin intramuscular 💉 injection buttock 11.25 mg 1∕12 weeks Pamorelin
2024-11-10 Estradiol transdermal 🧴 gel arm 2.25 mg 2∕day Oestrogel Stopped taking CPA due to (seemingly justified) expectation that Triptorelin flare is over.
Triptorelin intramuscular 💉 injection buttock 11.25 mg 1∕12 weeks Pamorelin
2025-03-07 Estradiol transdermal 🧴 gel arm  3 mg 1∕day Oestrogel Reduce dose because of high Estradiol levels in blood tests; lower dose in exchange for only once daily.
Triptorelin intramuscular 💉 injection buttock 11.25 mg 1∕12 weeks Pamorelin
2025-12-24 Estradiol transdermal 🧴 gel arm  3 mg 1∕day Oestrogel Start Progesterone.
Triptorelin intramuscular 💉 injection buttock 11.25 mg 1∕12 weeks Pamorelin
Progesteron oral 💊 capsule 200 mg 1∕day Utrogestan
2026-02-06 Estradiol transdermal 🧴 gel arm  3 mg 1∕day Oestrogel Start Minoxidil.
Triptorelin intramuscular 💉 injection buttock 11.25 mg 1∕12 weeks Pamorelin
Progesteron oral 💊 capsule 200 mg 1∕day Utrogestan
Minoxidil topical 💧 spray temples 6.7 mg 2∕day Teva Spray

Oestrogel here refers to Besins’ gel containing 0.6 mg Es­tra­di­ol (in the form of Es­tra­di­ol Hemihydrate) per 1 g of gel and dispenses 1.25 g of gel per pump, no matter the specific name they were marketed under. Felicitas’s gel is Homebrew-Estrogen.

I dosed accoring to claimed concentration and claimed dispensed amount. That said, the first Felicitas bottles were clearly not very reliable in producing fully consistent amounts, which usually meant less E than desired, often requiring multiple pumps to get an amount that visually matched the produced E at the start and might explain the low levels of E below. When I started the second bottle, it seemed to produce more which might have increased the dose.

Blood tests

Date Estradiol Testosterone SHBG Prolactin
2024-08-15 209 pmol∕l 1.40 nmol∕l 25.9 nmol∕l 56 µg∕l
2024-10-04 3324 pmol∕l 1.11 nmol∕l 32.5 nmol∕l 30 μg∕l
2025-03-05 1414 pmol∕l 1.79 nmol∕l 56.8 nmol∕l
2025-07-11 375 pmol∕l 1.10 nmol∕l 70.8 nmol∕l 16 μg∕l
2025-12-19 547 pmol∕l 0.84 nmol∕l 63.9 nmol∕l 18 μg∕l

Maasstad’s target range for Estradiol is 300-600 pmol∕l.

(Conversion from Maasstad’s “U∕l” into μg∕l, done by multiplication with 1 000μg21.2U\frac{1000~\mathrm{μg}}{21.2~\mathrm{U}} and rounding. It’s really annoying that they don’t use SI-units themselves…)

2024/04/24

This was the first time when I requested a blood test from my then GP, who refused to provide it.

2024/07/10

After talking with my genderclinic (Psytrans), and them trying to talk sense into my then GP, I requested a blood test again and was refused again.

I filed a malpractice complaint afterwards and considered myself to not have a GP since then, until I much later managed to find another one.

2024/08/15

After still not being able to receive a blood test from the healthcare system, I purchased a rather minimalist one privately for > 140 €.

The results here are for a low trough level, in that the blood draw was a bit more than 24 h after my previous dose.

Value Level low high Unit
Estradiol 208.5 pmol∕l
Prolactin 56.4 4.79  23.3 µg∕l
Testosterone 1.4  0.29  1.67 nmol∕l
SHBG 25.9  32.4  128.0 nmol∕l

The Estradiol reference levels were as follows:

Phase low high Unit
Follicular phase 98.0 572.5 pmol∕l
Ovulation 48.1 314.0 pmol∕l
Luteal Phase 121.5 1093.7 pmol∕l
Menopause 18.4 183.1 pmol∕l

2024/10/04

Maasstad Ziekenhuis, (unexpected, thus peak value few hours after gel application on the site of the draw). The reference values here are clearly masculine, which makes them pretty useless, but I’m including them for completeness. 🙄

Value Level low high Unit
Estradiol 3324  41.4  159 pmol∕l
Prolactin 0.63  0.09 0.32 U∕l
Testosterone 1.11  8.64 29 nmol∕l
SHBG 32.5  16.5  55.9 nmol∕l
LH < 1.0  1.7  8.6 U∕l
FSH < 1.0  1.5  12.4 U∕l
PLN, post PEG 0.53 0.06 0.25
Free Testosterone 20.0  198.0  619.0 pmol∕l
Vitamin D 26 50  150 nmol∕l

2025/03/05

Maasstad Ziekenhuis, (again unexpected, thus peak value few hours after gel application on the site of the draw).

Value Level low high Unit
Estradiol 1414 pmol∕l
Testosterone 1.79 0.101 1.42 nmol∕l
SHBG 56.8 24.6 122.0 nmol∕l
LH < 1.0 U∕l
Free Testosterone 23.1 3.0 33.0 pmol∕l

For completeness sake, the cycle-dependent referene ranges are as follows, though they famously don’t really apply to trans women, and that the intended value for LH and FSH are “below detectable” to begin with (as they should be in my case):

Hormone Phase low high Unit
Estradiol Follicular phase 0.114 332 pmol∕l
Ovulation 222 1959
Luteal Phase 222 854
Menopause < 18.4 505
1st Trimester 563 11902
2nd Trimester 5729 78098
3rd Trimester 31287 > 110100
Luteinizing Hormone Follicular phase 2.4 12.6 U∕l
Ovulation 13.0 95.6
Luteal Phase 1.0 11.4
Menopause 7.7 58.8

2025/07/11

Maasstad Ziekenhuis (this time deep trough values, since last dose was administered a bit more than 24 hours previously.)

Value Level low high Unit
Estradiol 375 pmol∕l
Prolactin 0.34 —   0.86 U∕l
Testosterone 1.10 0.101 1.42 nmol∕l
SHBG 70.8 24.6 122.0 nmol∕l
LH < 1.0 U∕l
FSH < 1.0 1.7 21.5 U∕l
Free Testosterone 12.1 3.0 33.0 pmol∕l
Vitamin D 48 50 150 nmol∕l

The reference ranges are all as before, so check the table in the previous section for the cycle-dependent reference ranges.

2025/12/19

Maasstad Ziekenhuis (again deep trough).

Value Level low high Unit
Estradiol 547 pmol∕l
Prolactin 0.39 —   0.86 U∕l
Testosterone 0.835 0.101 1.42 nmol∕l
SHBG 63.9 24.6 122.0 nmol∕l
LH < 1.0 U∕l
FSH < 1.0 1.7 21.5 U∕l
Free Testosterone 9.9 3.0 33.0 pmol∕l
Vitamin D 26 50 150 nmol∕l

The reference ranges are all as before, so check the table in the previous section for the cycle-dependent reference ranges.